Abstract
Abstract The presence of a large excess of p-aminosalicylic acid prevents the direct application of Vierordt’s spectrophotometric method to the determination of isoniazid in tablets. The method can, however, be applied after the bulk of the p-aminosalicylic acid has been removed with ether. The extinction of the aqueous phase containing all the isoniazid and some of the p-aminosalicylic acid is then determined at two wavelengths and the concentration of isoniazid calculated therefrom.
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