Abstract
A simple, sensitive and accurate spectrophotometric method for the determination of iron(II) in anti-anaemic pharmaceutical formulations was described. The method is based on the formation of a ternary complex of Fe(III) with a newly developed ligand, the isoniazid-p-diethylaminosalicylaldehyde hydrazone (IDSH) in Triton X-100 micellar medium. The apparent molar absorptivity at 471 nm and Sandell's sensitivity was 2.3×104 l mol−1 cm−1 and 2.43 ng cm−2, respectively. Beer's law is obeyed in a concentration range from 100 ppb to 5.0 ppm and the regression line equation was derived with a correlation coefficient of 0.9997 (n=8). The results obtained from the new method and those of the o-phenanthroline one, were compared statistically by means of the Student's t-test as well as by the variance ratio F-test and no significant difference was observed.
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