Abstract
Abstract Fluvoxamine was reacted with chloranil in aqueous ethanolic medium buffered at pH 9 to yield a complex with maximum absorption at 347 nm. The estimated molar absorptivity and stability constant of the complex were (1.30 ± 0.03) × 104 L mol−1 cm−1 and (1.7 ± 0.5) × 104 L mol−1 respectively. Absorbance at (δmax) was linearly related to concentration of fluvoaxamine over the range 2 to 25 μg ml−1 with a detection limit of 0.4 μg ml−1. The slopes of log-log plots of initial concentrations of fluvoxamine or chloranil vs. initial rate of color development were both unity. When the reaction was applied to commercial tablets (Faverin ρ −50) labeled to contain 50 mg of fluvoxamine maleate per tablet, the mean percentage found was 100.4 ± 1.0. Recovery experiments after standard additions and analysis of variance (ANOVA) were carried out to investigate the accuracy and precision of the proposed method. Reversed-phase high-performance liquid chromatography, (RP-HPLC), using μ-Bondapak C18 (30 cm × 3.9 mm, i...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
