Abstract
A new, simple, fast and sensitive two spectrophotometric methods has been developed for determination of Escitalopram in bulk and tablet dosage forms. The method A is based on the oxidation of Escitalopram by a known excess of bromate-bromide mixture in hydrochloric acid medium, reduction of the residual oxidant by a fixed amount of iron(II) and the formation of iron(III)-thiocyanate-complex which is measured at 480 nm. In the method B, 1,10-phenanthroline is used as a complexing agent and the formation of iron(II)-1,10-phenanthroline, which is measured at 510 nm.
Highlights
Escitalopram (Figure 1) is a pure S- enantiomer of the recemic, bicyclic phthalane derivative of citalopram
Escitalopram blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A auto receptors[3]
3.3 Applications: The proposed methods have agreement between the results obtained by the been applied to the determination of Escitalopram proposed methods and label Esc
Summary
Escitalopram (Figure 1) is a pure S- enantiomer of the recemic, bicyclic phthalane derivative of citalopram. It is freely soluble in methanol and Dimethylsulfoxide (DMSO). Escitalopram blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A auto receptors[3]
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