Abstract
A spectrophotometric method for determination of codeine is described. The method is based on the reaction of codeine with bromocresol green. The yellow complex formed was extracted with chloroform at pH 3.8. The solution of complex in chloroform showed maximum absorbance at 418 nm. The complex was stable up to 10 days and obeyed Beer's law over the concentration ranges of 3–12 μg/ml. The ratio of codeine to bromocresol green was 1:1. Excipients, coloring matter, flavoring agents and some other compounds likely to be present in the codeine-containing preparation did not interfere in the determination. The interferences can be eliminated by preliminary TLC separation.
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