Spectrophotometric determination of cobalt in multivitaminic preparations with dipyridylglyoxal mono (2-pyridyl) hydrazone

Abstract

A brief review on the determination of cobalt in pharmaceutical preparations as well as the spectrophotometric determination of cobalt in Hidropolivit Mineral — a complex multivitamin preparation — with the use of dipyridylglyoxal mono(2-pyridyl)hydrazone are reported in this paper. A procedure in which preliminary ashing is eliminated is followed in the sample preparation. Preliminary experiments were carried out in order to check that the presence of various vitamins and hormones had no adverse effects on the recovery of cobalt. Comparison of the variance and mean values obtained for cobalt in Hidropolivit Mineral by the proposed method ( x ± S.D. = 0.029 ± 0.003 mg of cobalt per tablet) and the biacetyl mono(2-pyridyl)hydrazone method for cobalt ( x ± S.D.=0.026 ± 0.002 mg of cobalt per tablet) using the variance ratio test and Student's t-test showed no significant differences between the two methods.