Spectrophotometric Determination of Chlorpromazine in Preparation with o-Sulfophenylfluorone and Gallium(III)

Abstract

A novel spectrophotometric method was established for the determination of chlorpromazine (CP) and other drugs with an o-sulfophenylfluorone-gallium(III) complex. In the determination of CP, Beer's law is obeyed in the range of 0.08∼2.0 μg/mL. The molar absorptivity and the relative standard deviation were 1.2 × 105 dm3 mol−1 cm−1 and 2.5% (n = 5), respectivery. Moreover, the method was successfully applied to assays of CP and other drugs in pharmaceutical preparations. The proposed method should be useful for simple and sensitive determinations of CP and other drugs.