Abstract
The nanostructure pharmaceutical formulations (NPF) which contains testosterone undecanoate (TU) been used in life science as parent compound delivery systems for therapeutic, but and been used to enhance the performance in sport, so it is a significant substance for public health and nutritional supplements. In most Pharmacopoeias testosterone is described as an ester of some lower acids (often propionate). The aim of this study is to determine purity of the parent compound by chromatography and absorption spectrum in the frame of middle infrared. Chemical structure of undecanoate was prepared and used in order to achieve a better absorption. This is explained by increased lipophilicity of undecanoate. Due to its lipophilic character, TU is soluble in non–polar solvents but shows a satisfactory solubility in absolute ethanol. Based on the molecular structure, a moderate absorption in the frame of UV with a maximum absorption at a not too high wave-length can be predicted. Maximum absorption occurs in a spectral region in which usual ingredients do not present significant interference.
Highlights
The nanostructure pharmaceutical formulations (NPF) which contains testosterone undecanoate (TU) been used in life science as parent compound delivery systems for therapeutic, but and been used to enhance the performance in sport, so it is a significant substance for public health and nutritional supplements
NPF like anabolic androgenic steroids (AAS) can be divided into the following the groups: analogues obtained by esterification of the 17–β–hydroxyl group; analogues alkylated in 17–α position; analogues with the modified nuclei A, B and C5
infrared frame (IR) absorption spectrum of the TU film dried from the dichloromethane solution deposited onto the CaF2 surface
Summary
The nanostructure pharmaceutical formulations (NPF) which contains testosterone undecanoate (TU) been used in life science as parent compound delivery systems for therapeutic, but and been used to enhance the performance in sport, so it is a significant substance for public health and nutritional supplements. NPF by the anabolic androgenic steroids (AAS) chemically produced are structurally related with the testosterone parent compound. The latter were adapted to improve its the pharmacological properties and anabolic effect of the testosterone (androst–4–ep–17–ol–30) over the protein, while in the same time reducing unwanted androgenic effects[4]. Most of the ASA present structural modifications in the nuclei A, B or C8 This type of steroid is often available for oral use, relevant to human nutrition aspects[9]. Other chemical substances related to the later are 5-androstenedione, 4-androstenediol, 5-androstenediol, 19-norandrosta-4-enedion, 19-norandrosta-5-enediol and 19-norandrosta-4-enediol Most of those steroids have no any known clinical recommendation[12]. The metabolic route includes oxidation, reduction, hydroxylation and epimerization reactions (Phase I) and conjugation reactions forming glucuronides and sulphate conjugates (Phase II reactions)[16,17]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
