Abstract
A simple rapid spectrophotometric method has been developed for estimation of cefuroxime axetil from bulk drug and tablet dosage form by using 1-nitroso-2-napthol and sodium hydroxide. The method is based on the formation of yellow-orange coloured complex of drug with 1-nitroso-2-napthol having absorbance maxima at 424 nm. The Beer’s law is obeyed in the concentration range of 10-50 μg/ml of the drug but more precisely it obeys in the range of 10- 30 μg/ml. The slope and intercept values are 0.0101 and 0.0838, respectively. Results of analysis of this method were validated statistically and by recovery studies. The method is applied to the marketed tablet formulation. Result of analysis of tablet formulation given as percentage of label claim ±standard deviation is 99.17±1.57. The precision and accuracy was examined by performing recovery studies and was found to be 99.50±1.82. Sandell’s correlation coefficient is calculated as 0.4434. The developed method is simple, sensitive and reproducible and can be used for routine analysis of cefuroxime axetil from bulk and tablet dosage form.
Highlights
Test compounds 11a-f exhibited signiÞcant inhibitory activity in PC-3 cell line and 11a-c were more active than Adriamycin at 10, 20 and 40 μg/ml concentrations
The present work led to synthesis of two series of L-glutamic acid amides and among these, tests compounds 2 and 11a-c exhibited potent anticancer activity in some of the cell lines tested
A simple rapid spectrophotometric method has been developed for estimation of cefuroxime axetil from bulk drug and tablet dosage form by using 1-nitroso-2-napthol and sodium hydroxide
Summary
Test compounds 11a-f exhibited signiÞcant inhibitory activity in PC-3 cell line and 11a-c were more active than Adriamycin at 10, 20 and 40 μg/ml concentrations. The present work led to synthesis of two series of L-glutamic acid amides and among these, tests compounds 2 and 11a-c exhibited potent anticancer activity in some of the cell lines tested. Spectrophotometeric Determination of Cefuroxime Axetil from bulk and in its tablet dosage form Et al.: Spectrophotometric analysis of cefuroxime Axetil
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
