Abstract
Abstract A new, simple and sensitive fluorimetric method for the determination of three pharmaceutical thiocompounds: cimetidine, thiabendazole and carbimazole, and also allopurinol, has been presented. The method is based on the fluorescence quenching of mercurochrome (MER) in an aqueous alkaline medium. Calibration graphs correlating the fluorescence difference (Fo-F) or the fluoresence ratio (Fo/F) of MER before (Fo) and after (F) quencher addition versus the concentration of the latter are linear. Such linearity permitted the successful application of
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