Spectro-luminescent characterization of molecular complex based on tryptanthrin for design of new effective drugs

Abstract

Optical absorption (at room temperature), fluorescence (at room temperature and T = 78 K) and phosphorescence (at T = 78 K) spectra of solution of the molecular complex based on tryptanthrin with platinum chloride and DMSO [Pt(Try)(DMSO)Cl2] (Try-Pt) was investigated. The positions of the first excited singlet (S1) and triplet (T1) energy levels were obtained. It was shown that in the excited state intramolecular singlet excitations energy transfer inside tryptanthrin π-electron system between two centers of optical absorption (that absorb equally) exists. It was found out the optical response of toxic influence of platinum chloride on tryptanthrin π-electron system inside this molecular complex as it is shown by us for a number of polynucleotides. Contrary to singlet energy transfer no intramolecular triplet electronic excitations energy transfer inside tryptanthrin π-electron system between both optical centers is observed. Taking into account the facts that such complexes can easy bind to telomeric G4 DNA the studied phenomena can be used for the design of new effective antitumor and anti-inflammatory drugs.