Abstract
Objective:To analyze the changes of the complementarity-determining region 3(CDR3) of T-cell receptor(TCR) beta chain variable region(TCR BV) in peripheral blood mononuclear cells(PBMCs) of patients with pemphigus vulgaris(PV),so as to understand the association of proliferated T cells with autoimmune diseases.Methods: Immunoscope spectratyping technique was used to analyze the distribution of TCR β chain CDR3 in 6 normal blood donors and the dominant CDR3 in the PBMCs in 6 PV patients.Results: The spectratypes of TCR BV subfamily CDR3 region was in a Gaussian distribution manner in all the 6 normal blood donors.The 6 PV patients,however,displayed abnormal proliferation,and oligoclonal expansion of the T cells was observed in TCR BV families with different CDR3 sequences.Conclusion: The abnormal spectratypes of TCR BV subfamily CDR3 region in the peripheral blood of PV patients might be related to the pathogenesis of PV.
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