Spectral time-course analysis of firing patterns in the dorsal cochlear nucleus

Abstract

Many previous studies of central auditory neurons have involved independent analyses of spectral and temporal response properties. The spectral response analysis is useful for defining the frequency and intensity regions over which a neuron is excited or inhibited. However, the conventional spectral response analysis only defines this distribution for the synaptic polarity (excitation or inhibition) which dominates the duration of the response. PST histograms of dorsal cochlear nucleus neurons however, often exhibit both excitatory and inhibitory (i.e. pause) components. The distribution of these transient pause intervals may in turn be highly dependent on stimulus parameters suggesting that the spectral area of excitation and inhibition, when considered in terms of short time frames, may be time-dependent. We performed a temporal analysis of the spectral response areas of neurons in the rat dorsal cochlear nucleus and present here an example based on a neuron showing distinct pauser and buildup responses in its PST histograms. The resulting analysis yielded a time course of the spectral response area which indicates that the transient periods of inhibition may have the effect of narrowing the bandwidth of excitation during the early portion of stimulation. Possible implications of this time course are discussed in relation to the narrower tuning that cochlear nucleus neurons often display in response to frequency sweeps than to pure tones.