Abstract
3-hydroxy-2-phenylchromen-4-one (HF) is a flavonols that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond. Cyclodextrins are able to form host-guest complexes with hydrophobic molecules given the unique nature imparted by their structure.As a result, these molecules have found a number of applications in a wide range of fields. The inclusion complex of HF with 2HP-β-CD is prepared by various synthetic method such as physical method (PM), kneading method (KM) and co-precipitation method (CP). The solid inclusion complex is characterized by UV, luminescence spectra, Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM) and powder X-ray diffraction (XRD). The anticancer activity of the solid complex is performed against breast cancer cell line and it is noticed that there is no much better activity than the HF alone. Both the HF and its solid complex showed the poor anticancer activity against MDA MB 231 cell line.
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