Spectral studies of interactions of detergents with tryptophyl compounds.

Abstract

The interactions of sodium dodecylsulfate and hexadecyltrimethylammonium chloride with typtophyl model compounds were investigated by fluorescence, classical difference spectra and thermal perturbation spectra. Oppositely charged models and detergents interact to produce marked spectral changes. Apolar interactions also contribute. The ease of interaction with sodium dodecylsulfate decreases in the order: tryptamine, Lys‐Trp‐Lys, Leu‐Trp‐Leu, Gly‐Trp‐Gly, Glu‐Trp‐Glu shows little or no interaction. Lys‐Trp‐Lys forms both soluble and insoluble complexes with sodium dodecylsulfate.