Spectral studies of Donepezil release from streched PVA polymer films

Abstract

The focus of this research is to obtain poly vinyl alcohol (PVA) polymer foils containing Donepezil in different concentration, in order to be used in controlled drug release as a palliative treatment of mild to moderate Alzheimer’s disease. The influence of polymeric foil stretching degree on drug release was analyzed using spectral measurements.Aiming to evidence the stretching degrees of PVA foils influence on drug release the membranes containing 2% Donepezil were obtained and characterized. The morphology of pure PVA and polymeric films with Donepezil at different stretching degrees was investigated.In vitro evaluation of drug release from the polymeric foils was made for different stretching degrees. The absorbance of the solution was measured at 232nm in each case; the amount of drug release after each time interval was calculated and a cumulative addition was made. The mechanism involved in drug release process was evaluated using Korsmeyer–Peppas empirical equation. Surface roughness and profile of drug release are affected by the stretching degree of PVA foils.The dependence of the release profile on the characteristics of polymer foils containing Donepezil and the manner in which the stretching degree of the PVA with Donepezil films modify the kinetics of drug release were emphasized in this study.