Abstract
Cone-beam X-ray luminescence computed tomography (CB-XLCT) has become a promising technique for its higher utilization of X-ray and shorter scanning time compared to the narrow-beam XLCT, but it suffers from the low-spatial resolution that results in the insufficiency to resolve the adjacent multiple probes. In multispectral CB-XLCT, multiple probes show different emission behaviors in the dimension of the spectrum. In this work, a spectral-resolved CB-XLCT method combining multispectral CB-XLCT with principle component analysis (PCA) was proposed to improve the imaging resolution. Results of digital simulation and the phantom experiment illustrated that the proposed method was capable of resolving adjacent multiple probes accurately and had better performance than the common multispectral CB-XLCT with spectrum information priori.
Highlights
The feasibility of X-ray luminescence computed tomography (XLCT) was first demonstrated by Xing’s group in narrow-beam X-ray mode [1]
Cone-beam X-ray luminescence computed tomography (CB-XLCT) has got development for its higher utilization of X-ray and shorter scanning time compared to the narrow-beam XLCT, but it suffers from the low-spatial resolution due to the ill-posed optical reconstruction
A spectral-resolved CB-XLCT method which combined multispectral CB-XLCT with principle component analysis (PCA) was proposed for multiple probe imaging, and the performance was evaluated by digital simulation and phantom experiment further
Summary
The feasibility of X-ray luminescence computed tomography (XLCT) was first demonstrated by Xing’s group in narrow-beam X-ray mode [1]. Compared to the narrow-beam and fan-beam mode, CB-XLCT can illuminate the whole body and stimulate all the nanoparticles simultaneously, so it can improve the X-ray utilization and reduce the scanning time greatly which is critical for clinical application. CB-XLCT suffered from the ill-posed reconstruction which resulted in low-spatial resolution, and the ill-posed problem became worse for in vivo imaging due to the high scattering characteristic of photons in biological tissue. As a result, it is a challenge for CB-XLCT to resolve multiple probes especially when they are adjacent
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