Spectral-Domain Optical Coherence Tomography in Hydroxychloroquine Retinopathy

Abstract

In 2011, revised guidelines for screening chloroquine and hydroxychloroquine (HCQ) retinopathy recommended spectral-domain optical coherence tomography (SD OCT), fundus autofluorescence, or multifocal electroretinogram in addition to ophthalmologic examination and 10-2 perimetry. 1 Marmor M.F. Kellner U. Lai T.Y.Y. et al. Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy. Ophthalmology. 2011; 118: 415-422 Abstract Full Text Full Text PDF PubMed Scopus (457) Google Scholar To date, the qualitative features of SD OCT in chloroquine and HCQ retinopathy have been reported in <60 patients, most of whom had established retinopathy. Also, thinning of parafoveal retina has been documented, 2 Ulvive Y. Betul T. Hatice Nur T. Selda C. Spectral domain optical coherence tomography for early detection of retinal alterations in patients using hydroxychloroquine. Indian J Ophthalmol. 2013; 61: 168-171 Crossref PubMed Scopus (18) Google Scholar , 3 Seamone M. Milton K. Deschenes M. et al. A comparison of spectral domain optical coherence tomography and multifocal electroretinography findings in hydroxychloroquine retinopathy. Invest Ophthalmol Vis Sci. 2013; (E-Abstract 3597): 54 Google Scholar occurring even when cross-sectional scans are equivocal. 4 Marmor M.F. Comparison of screening procedures in hydroxychloroquine toxicity. Arch Ophthalmol. 2012; 130: 461-469 Crossref PubMed Scopus (129) Google Scholar