Spectral domain optical coherence tomography in children: normative data and biometric correlations.

Christiane Al-Haddad,Baha’ Noureddin,Anita Barikian,Vicky Massoud,Mahmoud Jaroudi,Hani Tamim

doi:10.1186/1471-2415-14-53

Christiane Al-Haddad, Baha’ Noureddin + Show 4 more

Open Access

https://doi.org/10.1186/1471-2415-14-53

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Journal: BMC ophthalmology	Publication Date: Apr 22, 2014
Citations: 84	License type: CC BY 2.0

Affiliation: American University of Beirut

Abstract

BackgroundThe aim was to report normative values of retinal nerve fiber layer (RNFL) and macular parameters in children using spectral domain optical coherence tomography (OCT) and to perform correlations with age, refractive error and axial length.MethodsThis was an observational cross-sectional study recruiting 113 healthy children aged 6 to 17 years with no ocular abnormality except refractive error. After a comprehensive eye examination and axial length measurement, RNFL and macular thickness measurements were performed using the Cirrus OCT machine. Main outcome measures were macular volume, macular thickness and RNFL thickness values as well as their correlations with age, refractive error and axial length. Right eyes of all subjects were selected for analysis.ResultsOne hundred and eight children were included in the study, 65 females and 43 males. Mean age was 10.7+/−3.1 years, average spherical equivalent refraction (SE) was −0.02+/−1.77(−4.25 to +5.00) diopters and average axial length was 23.5+/−1.0 (21.5 to 25.8)mm. Mean RNFL thickness was 95.6+/−8.7 μm, average macular thickness was 279.6+/−12.5 μm, central macular thickness was 249.1+/−20.2 μm, and mean macular volume was 10.1+/−0.5 mm3. Central macular thickness values were significantly higher in males (p < 0.001). RNFL measurements did not correlate with age but did show a positive correlation with SE. All macular parameters were consistently positively correlated with age and most of them were positively correlated with SE. When controlling for axial length, only the macular inner circle thickness was positively correlated with age.ConclusionsUsing Cirrus OCT, normative RNFL and macular parameters in healthy children below 18 years of age were established; measurements varied by age and gender.

Highlights

The aim was to report normative values of retinal nerve fiber layer (RNFL) and macular parameters in children using spectral domain optical coherence tomography (OCT) and to perform correlations with age, refractive error and axial length
All macular parameters were consistently positively correlated with age and most were positively correlated with spherical equivalent refraction (SE) (Table 3).When controlling for axial length, correlation with SE was lost and only the positive correlation of the inner circle macular thicknesses with age persisted
Correlations with biometric data showed that central macular but not RNFL thickness values were higher in males; the macular inner circle thickness correlated positively with age and average RNFL thickness correlated positively with SE

Summary

Introduction

The aim was to report normative values of retinal nerve fiber layer (RNFL) and macular parameters in children using spectral domain optical coherence tomography (OCT) and to perform correlations with age, refractive error and axial length. The recently introduced spectral domain OCT (SD-OCT) provides measurements of the retinal nerve fiber layer (RNFL) and macula with greatly improved image acquisition speed and image resolution up to 5 μm [1]. This is helpful when applying this technology in uncooperative children. Normative measurements in children using Cirrus are least reported, especially with regards to macular parameters

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