Abstract
In this work, photoinduced delayed luminescence (DL) was used to distinguish serum samples of patients with acute lymphoblastic leukemia from those of healthy volunteers. DL decay kinetics of human serum samples was measured using a homebuilt ultraweak luminescence detection system. It was found a significant difference in the weight distribution of the decay rate between normal and leukemic serum samples. A comparison of the DL kinetics parameters including the initial intensity, the peak decay rate, and the peak weight value was used in making discrimination between normal and leukemic human sera. Results in this work contribute to the development of a novel optical method for the early diagnosis of leukemia.
Highlights
Serum, the portion of blood plasma that consists of non-coagulating proteins, electrolytes, antibodies, antigens, hormones, and any exogenous substances, represents an important biological material for disease diagnosis [1,2,3,4]
With the aim of developing a novel diagnostic method of leukemia, we report in this paper the use of delayed luminescence (DL) to spectrally discriminate between normal and leukemic human sera
The background count is about 32 c/s in the magnitude, which could be neglected when compared to the DL intensities of serum samples within 1 s after illumination
Summary
The portion of blood plasma that consists of non-coagulating proteins, electrolytes, antibodies, antigens, hormones, and any exogenous substances, represents an important biological material for disease diagnosis [1,2,3,4]. One recent achievement is that absorption spectroscopy has been applied to discriminate between normal and leukemic human sera based on intensity ratio measurements [7] It is a quick method for making preliminary evaluation, but its accuracy is only about 80%. Previous investigations have shown that there is a close correlation between the parameters of DL and the characteristics of organisms, such as the biological activity, injury, physiological and pathological changes [10,11,12,13,14,15] Owing to this striking correlation and the advancement of ultraweak light detection technology, it is possible to obtain information about the changes of substance components and biochemical reactions in serum by using DL as a fast, sensitive optical indicator [16]. With the aim of developing a novel diagnostic method of leukemia, we report in this paper the use of DL to spectrally discriminate between normal and leukemic human sera
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