Abstract
A series of bivalent Cu2+, Cd2+, and Mn2+ metal complexes were prepared with 6-fluoro-3-hydroxypyrazine-2-carboxamide (favipiravir) ligand (L) and structurally characterized via many spectroscopic techniques (IR, UV–vis, 1H NMR, 13C NMR, ESI-MS & powder XRD) besides the elemental analysis and magnetic moment measurements. The complexes were also investigated by thermal studies (TG/DTA) accompanied by kinetic investigations based on Coats-RedfernandHorowitz-Metzgerintegralmethods. The ligand and its metal complexes were geometric optimized using the Gaussian 09 view based on DFT theory. Through cyclic voltammetric scanning with/without the ligand, the complexation effect on Cu+2 was studied electrochemically in solution. Finally, the antimicrobial assays including (Escherichia coli, Bacillus cereus, and Candida albicans) were screened for all compounds to calculate the % activity index and MIC. In addition, the antioxidant activity was investigated using DPPH and TAC assays.
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