Abstract
Progress in laser and camera technology has simplified the acquisition of laser speckle images relating to dermal blood flow. Using speckle contrast measurements over 5 decades of exposure time, we show that a temporal autocorrelation function, and hence spectral information and a perfusion index precisely equivalent to that produced in Doppler methods, can be derived from speckle measurements. The autocorrelation data are well approximated by a simple but nonexponential function which is parametric in a characteristic time τ<sub>c</sub>. We suggest that the perfusion index could be found simply by determining τ<sub>c</sub> from a small number of speckle measurements at appropriate exposures. This is illustrated by measurement of perfusion recovery following an induced change in perfusion.
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