Abstract
The lanthanide(III) complexes of general formula of [Ln(APINH) 2 (NO 3 ](NO 3 ) 2 .nH 2 O (where, Ln = La, Ce, Pr, Nd, Sm; APINH = 2-acetylpyridine isonicotinoyl hydrazone, n = 0, 2 and 5 for La/Ce/Pr, Sm and Nd complexes, respectively) were synthesized under mild reaction conditions with excellent yields. The complexes were characterized based on elemental analysis, molar conductivity, and infrared spectroscopy. Molar conductivity data suggest that the complexes are 1:2 electrolytes. IR spectral data suggest that APINH acts as neutral tridentate ligand. Spectral data of complexes suggest that the ligand binds metal ion through pyridine- nitrogen, azomethine-nitrogen and amido-oxygen donor atoms. Electrochemical behaviour of metal complexes was investigated by using cyclic voltammetry. The complexes undergo quasi-reversible one electron reduction. The binding interaction of complexes with CT-DNA was investigated using absorption spectrophotometry. Based on spectral changes, groove binding of complexes to DNA is suggested. KEY WORDS : Lanthanide(III) complexes, 2-Acetylpyridine isonicotinoylhydrazone, Spectral characterization, DNA binding Bull. Chem. Soc. Ethiop. 2016 , 30(2), 221-230. DOI: http://dx.doi.org/10.4314/bcse.v30i2.6
Highlights
Investigations of lanthanide complexes with polydentate ligands have received considerable attention because of their potential applications in various fields [1,2,3,4,5,6,7,8,9,10,11]
Though Sacconi has reported [12] lanthanide complexes of acetylacetone isonicotinoyl hydrazone in the year 1954, a literature review [13,14,15] indicated that the study of such complexes is relatively less when compared with transition metal complexes with this class of ligands
In the light of the above and in continuation of earlier work [28, 29] on DNA binding and cleavage activities of transition metal complex, we report synthesis, spectral characterization and DNA binding properties of lanthanide(III) complexes of 2-acetylpyridine isonicotinoylhydrazone for the first time
Summary
Investigations of lanthanide complexes with polydentate ligands have received considerable attention because of their potential applications in various fields [1,2,3,4,5,6,7,8,9,10,11]. In the light of the above and in continuation of earlier work [28, 29] on DNA binding and cleavage activities of transition metal complex, we report synthesis, spectral characterization and DNA binding properties of lanthanide(III) complexes of 2-acetylpyridine isonicotinoylhydrazone for the first time. Spectral characterization and DNA binding properties of lanthanide(III) complexes 223 more than four days. The electronic spectra of metal complexes in aqueous solutions were monitored in the absence and presence of CT-DNA.
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