Abstract
To investigate the treatment effect of additional information obtained by single photon emission computed tomography (SPECT) lung perfusion imaging (LPI) in the radiotherapy planning process for patients with stage III non-small cell lung cancer (NSCLC). 39 patients with stage III NSCLC were enrolled. Gross tumor volume (GTV) was outlined by SPECT/CT images, SPECT-LPIs being used to define functional lung (FL) and non-functional lung (NFL) regions. Two sets of IMRT plans were designed to deliver 64Gy to PTV. One was a regular IMRT plan using CT images only (Plan 1), and the other was a corresponding IMRT plan using co-registered images (Plan 2). FLVx (the % volume of functional lung receiving ≥x Gy) and WLVx (% volume of whole lung to receive ≥x Gy) were compared by paired Student's t test. Kendalls correlation was used to analyze the factor (s) related with the FLV20 decrease. Compared with plan 1, both WLVx and FLVx were decreased in plan 2. WLV10, WLV15, WLV20, WLV25, WLV30 and WLV35 decreased 9.7%, 13.8%, 17.2%, 12.9%, 9.8% and 9.8%, and FLV10, FLV15, FLV20, FLV25, FLV30 and FLV35 decreased 10.8%, 14.6%, 17.3%, 14.5%, 14.5% and 10.5%. FLVx decreased significantly compared with WLVx. There were significant differences in WLV10, WLV15, WLV20, WLV25, WLV3 and FLV10, FLV15, FLV20, FLV25, FLV30 between plan 1 and plan 2 (P=0.002, 0.000, 0.000, 0.005, 0.027 and 0.002, 0.000, 0.000, 0.006, 0.010). According to Kendall correlation analysis, NFL had a negative relation with the percentage FLV20 decrease (r=-0.559, P<0.01), while the distance of PTV and NFL center had a significantly positive relation with the percentage of FLV20 decrease (r=0.768, P<0.01). Routine use of SPECT-LPI for patients undergoing radiotherapy planning for stage III NSCLC appears warranted.
Highlights
Lung cancer is the leading cause of cancer related mortality worldwide (Parkin et al, 2005)
A benefit can be enhanced in some cases with intensity modulated radiotherapy (IMRT) compared to three-dimensional conformal radiotherapy (3-DCRT), which may allow for improving planning target volume (PTV) coverage and better selective avoidance of normal tissues, when the targets are of complex shape lying in close proximity to critical structures
In this paper we investigated Systems Fortee gamma camera) using low energy, high whether the additional information obtained by single photon emission computed tomography (SPECT)- resolution collimators in the same position as that of the lung perfusion imaging (LPI) in the treatment planning process resulted in better PET/CT simulation by lying in the same vacuum pillow
Summary
Lung cancer is the leading cause of cancer related mortality worldwide (Parkin et al, 2005). C) Marks in single photon emission computed tomography (SPECT) co-registered images lung perfusion imaging (LPI) provides information about the functioning of pulmonary vascular/alveolar subunits where 99mTc labeled albumin adheres to the functional vasculature of the pulmonary vessels. A few studies have incorporated SPECT-LPI images into the treatment-planning process for lung positioned on bony landmarks over the anterolateral tumors In this paper we investigated Systems Fortee gamma camera) using low energy, high whether the additional information obtained by SPECT- resolution collimators in the same position as that of the LPI in the treatment planning process resulted in better PET/CT simulation by lying in the same vacuum pillow. Individually for each patient in order to match the size of the SPECT-LPI image to within the lung volumes defined.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
