Abstract
Five right-handed children with Landau-Kleffner syndrome (LKS) were studied with EEG and single-photon emission computed tomography (SPECT) before and after 6 months of corticosteroid therapy at the Universities of Estadual de Campinas and Sao Paulo, Brasil.
Highlights
The safety of antiepileptic drug (AED) withdrawal in 65 children with cerebral palsy (CP) who had been seizure-free for at least 2 years was investigated in the Neurology Department, Texas Scottish Rite Hospital for Children, Dallas
Epileptiform EEG abnormality, type of CT abnormality, family history of epilepsy, mono or polytherapy, and gender were not correlated with risk of seizure relapse
Steroids and AEDs had no significant beneficial effects on either aphasia or behavior
Summary
The introduction of antiepileptic treatment after a first or second seizure in children with generalized tonic-clonic or partial seizures requires further evaluation. Some previous studies have found that risk factors for seizure relapse after withdrawal of antiepileptic treatment have included delay in initiation of therapy. AED WITHDRAWAL IN CHILDREN WITH CEREBRAL PALSY
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