Abstract
Purpose: Post-traumatic osteoarthritis (PTOA) describes osteoarthritis initiated by traumatic injury which often involves a form of aberrant joint loading. Oxidant production in articular cartilage is known to increase with tissue loading, and oxidative damage in cartilage is associated with both mechanical injury and progression of PTOA. However, the precise mechanistic contributions of mechanical loading to PTOA and oxidative stress have not been described. To investigate the relationship between specific mechanical loading characteristics and chondrocyte oxidative damage, we have developed specimen-specific 3D finite element (FE) models of an impact injury which can be compared to meticulously oriented immunohistological (IHC) sections labeled for 3-nitrotyrosine modified proteins (3-NT), a marker of tissue oxidation.
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