Abstract
Hidradenitis suppurativa (HS) is a chronic inflammatory disorder characterized by painful nodules, sinus tracts, and scars occurring predominantly in intertriginous regions. The prevalence of HS is currently 0.053–4%, with a predominance in African-American women and has been linked to low socioeconomic status. The majority of the reported literature is retrospective, population based, epidemiologic studies. In this regard, there is a need to establish a repository of biospecimens, which represent appropriate gender and racial demographics amongst HS patients. These efforts will diminish knowledge gaps in understanding the disease pathophysiology. Hence, we sought to outline a step-by-step protocol detailing how we established our HS biobank to facilitate the formation of other HS tissue banks. Equipping researchers with carefully detailed processes for collection of HS specimens would accelerate the accumulation of well-organized human biological material. Over time, the scientific community will have access to a broad range of HS tissue biospecimens, ultimately leading to more rigorous basic and translational research. Moreover, an improved understanding of the pathophysiology is necessary for the discovery of novel therapies for this debilitating disease. We aim to provide high impact translational research methodology for cutaneous biology research and foster multidisciplinary collaboration and advancement of our understanding of cutaneous diseases.
Highlights
Www.nature.com/scientificreports frequently in women and patients of African descent[1,4,5,6]
We propose a Hidradenitis suppurativa (HS)-specific biobanking protocol to establish a standardized process for consistent and ethical data collection and analysis for future clinical and basic science studies
Biobanks are well-organized collections of human biological material which are stored for research and can help drive translational research[10,11,12]
Summary
Hidradenitis suppurativa (HS) is a chronic inflammatory disorder characterized by painful nodules, sinus tracts, and scars occurring predominantly in intertriginous regions. The majority of the reported literature is retrospective, population based, epidemiologic studies In this regard, there is a need to establish a repository of biospecimens, which represent appropriate gender and racial demographics amongst HS patients. There is a need for better understanding of the pathogenesis of HS and development of novel therapies To this end, we propose a HS-specific biobanking protocol to establish a standardized process for consistent and ethical data collection and analysis for future clinical and basic science studies. Biobanking is important for complex and largely understudied diseases like HS10,12 This protocol was successfully instituted at the Johns Hopkins University School of Medicine (JHUSOM) and has already contributed to translational studies[17].
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