Specifics of oxidative stress and antioxidant system in children with Crohn disease and ulcerative colitis

Abstract

The results of studies of the level of biomarkers of oxidative stress and the antioxidant system in children with Crohn’s disease and ulcerative colitis are presented. The relationship between nosology and the feature of redox imbalance was demonstrated, which was proved by a significant difference in the level of reduced glutathione in erythrocytes between groups of subjects. Children with Crohn’s disease have a lower level of reduced erythrocyte glutathione compared to patients with ulcerative colitis. This pattern can be explained by different types of inflammation in these diseases. Crohn’s disease has a productive granulomatous chronic inflammation, in which one of the mechanisms of development and flow is incomplete phagocytosis. Oxidative stress and deficiency of glutathione, which is part of the antioxidant system, make a large contribution to the defect in phagocytosis, and the persistence of oxidative imbalance will lead to an increase in inflammation activity due to the preservation of immune dysregulation. The study presents a variant of using binary logistic regression to search for a model of a method for the differential diagnosis of inflammatory bowel diseases, where the independent variable is the content of reduced erythrocyte glutathione.