Abstract
Aim. To assess the specifics of lipid metabolism and efficacy of atorvastatin therapy in Saint-Petersburg citizens, having 2 type diabetes (DM2) — the carriers of various TaqIB gene polymorphisms, the cholesterol ethers transporting protein (CETP). Material and methods. Totally 382 patients studied, with DM2, native for statins, and 187 almost healthy individuals. All participants underwent blood sampling with lipids test and molecular-genetic testing. Into atorvastatin group we included 164 patients with DM2 and dyslipidemia. Lipid profile parameters were assessed at baseline and in 3 months of atorvastatin therapy. Results. In almost healthy individuals the carriage of B1B2 genotype of TaqIB polymorphism of CETP gene is associated with higher levels of triglycerides, low density lipoproteides cholesterol, very low density cholesterol and atherogenity coefficient, comparing to these values in B2B2 carriers. DM2 patients had higher triglycerides level if B1B1 comparing to B2B2. In DM2 type, triglycerides level also was higher in B1B1 than in B2B2 (p=0,044); other lipid spectrum parameters did not differ between two groups. While comparing the efficacy of atorvastatin therapy in various genotypes carriers of TaqIB polymorphism gene CETP, there were no differences of the studied parameters within treatment. While evaluating the target levels reach of lipid spectrum on the atrovastatin therapy it was found, that only B1B1 carriers reached target triglycerides level (p=0,017). Conclusion. In DM2 patients the arrangement of genotypes and alleles of TaqIB polymorphism of CETP gene did not differ of this in healthy individuals; in carriers of different genotypes of this gene lipidogram parameters at baseline and on treatment by atorvastatin for 3 months did not differ; in B1B1 carriers the levels of triglycerides reached target values on atorvastatin.
Highlights
В связи с этим, целью данного исследования было определить особенности липидного обмена и эффективность терапии статинами у больных СД 2 типа — носителей различных генотипов TaqIB полиморфизма гена CETP, — проживающих в Санкт-Петербурге.
Таблица 1 Показатели липидного спектра крови у практически здоровых лиц — носителей В1В1, В1В2, В2В2 генотипов TaqIB полиморфизма гена белка, переносящего эфиры холестерина
Таблица 2 Показатели липидного спектра крови у больных сахарным диабетом 2 типа — носителей В1В1, В1В2, В2В2 генотипов TaqIB полиморфизма гена белка, переносящего эфиры холестерина
Summary
В связи с этим, целью данного исследования было определить особенности липидного обмена и эффективность терапии статинами у больных СД 2 типа — носителей различных генотипов TaqIB полиморфизма гена CETP, — проживающих в Санкт-Петербурге. Таблица 1 Показатели липидного спектра крови у практически здоровых лиц — носителей В1В1, В1В2, В2В2 генотипов TaqIB полиморфизма гена белка, переносящего эфиры холестерина
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