Abstract
The effect of a number of thyroxine analogs has been evaluated using kidney tissue respiration during prolonged incubation. Thyroxine was found to be the most active compound studied. All substances with marked thyroxinelikc activity had a skeletal structure of a diphenyl ether with at least three substitutions on the rings. lodo, methyl, bromo, chloro and nitro substitutions activated with decreasing effectiveness in that order. Variation in the number of carbon atoms, alteration of the optical configuration of the alanine side chain or its replacement by a short-chain fatty acid caused only slight reduction of the activity of an analog, as did the replacement of the ether oxygen with a sulfur. The results can be correlated with those from in vivo experiments and suggest that the thyroxine effect on tissue respiration in this type of system may yield information of value in explaining the hormone’s mechanism of action in whole animals.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
