Abstract
Rat liver microsomes contain a delta 6 desaturase that is active not only with the unsaturated acids of 18 carbons: oleic, linoleic and alpha-linolenic but also with similar acids of 20 carbons with the double bonds in delta 9, 12 and delta 12, 15. The rate of the reaction increases with the number of double bonds of the substrate but the acids of 20 carbons are less desaturated than the corresponding homologs of 18 carbons proving that the enzyme recognizes the number and position of double bonds as well as the chain length. The investigation of the inhibitory effect of different poly-unsaturated acids suggests that the acids would not only bind to the enzyme by means of the -CoA but also by other parts of the molecule different of the active center. The geometry of the molecule would be a substantial factor.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
