Abstract
A human T-cell line (CCRF-HSB2) was exposed in vitro to various doses of X rays (50, 100, and 200 rad) and analyzed at the first mitotic division for structural chromosome aberrations. When chromosome and chromatid deletions and chromosome exchanges were analyzed with respect to sites of breakage and reunion, nonrandomness was observed, both between and within chromosomes. A marked concentration of deletions and exchanges occurred in chromosome groups F, D, and B. One of the characteristics was the occurrence of homologous chromatid exchanges in groups F, D, and C. The distribution of breaks was also analyzed in chromosome preparations stained for G- and Q-bands. All the breaks were located at lightly stained chromosome segments, with clusters of breaks at some sites. A significant concentration of break-points in deletions and chromatid exchanges was seen at certain chromosomal sites, i.e., 1q11, 2p11, 2q11, 4p11, 4q12, 4q31, 5q13, 6q21, 7q11, 7q22, 11p13, 12p11, 14q13, and 20q11. The results suggest a s...
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