Abstract
The adenylate deaminase activity of the mitochondrial fraction of rat liver was stimulated in vivo not only by serotonin (5-HT) or other biogenic and synthetic indolylalkylamines, but also by phenyl- and imidazolealkylamines. 5-HT also stimulated adenylate deaminase activity of the liver mitochondria of CBA mice. Actinomycin D or cycloheximide, inhibitors of protein biosynthesis, prevented the stimulation of adenylate deaminase activity by 5-HT. Theophylline, a phosphodiesterase inhibitor, gave a similar effect only in the presence of a high degree of stimulation of adenylate deaminase activity.
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