Abstract
Lambdoid phage late gene operons are positively regulated by genome-specific antiterminator proteins encoded by the Q gene of each phage. In this paper, we compare the activity of phage λ and phage 82 Q proteins. Q82-mediated antitermination, like that of Qλ, involves a transcription pause during which the regulator can modify RNA polymerase. We show that the activities of both Q82 and Qλ are genome-specific in chasing RNA polymerase out of the early pause sites and in mediating antitermination. Finally, we show that the length of the RNA in the paused complex, or the exact position of the pause, affects the efficiency with which Q82 chases RNA polymerase out of the pause.
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