Abstract
This special issue of the Journal of Integrative Bioinformatics presents an overview of COMBINE standards and their latest specifications. The standards cover representation formats for computational modeling in synthetic and systems biology and include BioPAX, CellML, NeuroML, SBML, SBGN, SBOL and SED-ML. The articles in this issue contain updated specifications of SBGN Process Description Level 1 Version 2, SBML Level 3 Core Version 2 Release 2, SBOL Version 2.3.0, and SBOL Visual Version 2.1.
Highlights
11 University Medicine Greifswald, Greifswald, Germany. https://orcid.org/0000-0002-5886-5563. This special issue of the Journal of Integrative Bioinformatics presents an overview of COMBINE standards and their latest specifications
Standards play an important role in Systems and Synthetic Biology
COMBINE published the first collection of Systems and Synthetic Biology standards as a special issue of the Journal of Integrative Bioinformatics in 2015 [5]
Summary
Standards play an important role in Systems and Synthetic Biology. COMBINE (‘COmputational Modeling in BIology’ NEtwork) [1], [2] is a formal entity that coordinates standards development in these fields of research, fosters and moderates discussions, designs and implements dissemination strategies, and organises two annual community meetings each year. COMBINE describes itself as “...a network formed by the communities developing standards and formats to share computational models. The COMBINE web site https://co.mbine.org/ and COMBINErelated publications [1], [2], [4] provide more information. Please note that this editorial contains similar information to overviews in earlier special issues [5], [6], [7]. COMBINE published the first collection of Systems and Synthetic Biology standards as a special issue of the Journal of Integrative Bioinformatics in 2015 [5]. The latest update was published in 2018 [7] This special issue presents developments of standards and related initiatives in 2018/19
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