Abstract
AbstractFive radioactive and three deuterium labelled 1.2,3,4‐tetrahydro‐beta‐carbolines (THBCs) have been synthesized from tryptamine hydrochloride or 5‐methoxytryptamine hydrochloride and formaldehyde, glyoxylic acid or pyruvic acid. Radioactive labelling was performed using [14C] and [3H]labelled compounds. while the deuterium labels were introduced using lithium aluminium deuteride. The specific activities obtained for [14C] labelled THBCs varied between 1.0 and 5.0 mCi/mmol, while a value of 30.1 mCi/mmol was obtained for the tritiated compound. The isotopic purities of the deuterated THBCs were in the range of 76.3 ‐ 96.2 %.
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