Specific thyroid status and iode supply in pregnant women in Yakutsk city and rural locations

Abstract

Insufficient iodine intake in the body of pregnant women may lead to failure of adaptive and compensatory mechanisms, development of hormonal decompensation in the form of decreased synthesis of thyroid hormones and disorders of development and formation of the child's body. The aim of the work is to evaluate the peculiarities of thyroid status and iodine supply in pregnant women of Yakutsk city and rural areas. Materials and methods. Sixty-eight pregnant women in the 2-3rd trimester of pregnancy in Yakutsk city and rural areas participated in the study. The indicator of urinary iodine excretion was used to assess the degree of iodine deficiency. The level of urinary iodine excretion (ioduria) was determined by inductively coupled argon plasma mass spectrometry. The results can be summarized a s follows: the mean urinary iodine concentration in pregnant women living in Yakutsk and in rural areas was in the range of mild iodine deficiency (59 and 84 μg/L, respectively, the differences were statistically significant at p=0.06). It was found that in rural areas the degree of iodine deficiency was less pronounced - the median urinary iodine concentration ranged from 58.5 to 126 μg/l. Conclusion. The territory of Yakutia belongs to the geochemical regions where the degree of iodine deficiency is pronounced. However, the research conducted has shown that the degree of iodine deficiency in the city of Yakutsk and in rural areas is mild. The data obtained confirm the results of research, which indicate that in conditions of iodine deficiency, adaptation mechanisms are activated in the indigenous population.