Specific Proteins in Relation with Iron Overload in Experimental Study

Abstract

Iron is an essential mineral for organisms and due to environment iron deficiency and pollution it is very important to understand and monitor the iron homeostasis. Thus, the concentration of iron is very important in hematological and biochemical parameters because iron is component of hemoglobin, erythrocytes, and myoglobin -being part of oxygen-binding proteins. The aim of our experiment was to try a natural protection with fresh, organic plants administration � of iron overload in rabbits. Thereby, we administrated ferrous gluconate (hydro-solution, 15g Fe2+/body weight) as intraperitoneal injection for 43 days to German Lop Eared breed rabbits, and in the same time we tried to protect the animals with a diet consisting in black cumin seeds; clover, chives, leek, parsley, coriander, rucola, radish, fenugreek - leaves; cucumber and carrots. At the end of experiment we analyzed the protein electrophoresis (albumin, a1-globulin, a2-globulin, b1-globulin, b2-globulin and g-globulin), total iron binding capacity, and transferrin concentration. The analytical results demonstrated that plant administration was beneficial for iron homeostasis and the tested blood parameters did not record significant variations between control and experimental group, which proves that diet is very important in health and homeostatic mechanisms in living organisms.