Abstract

In vivo studies undertaken in higher animals (Littlefield et al., 1955; Simkin and Work, 1957) and bacteria (McQuillen and Britten, 1959) have permitted assigning to the ribosomes a primary role in protein synthesis. This synthesis seems to be accomplished principally by the cytoplasmic membrane in bacteria (McQuillen and Britten, 1959), which apparently contains ribosomes intimately associated with the cytoplasmic membrane. Studies have been undertaken to isolate from protoplasts a subcellular system capable of carrying out protein synthesis (Nisman and Fukuhara, 1959a).

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