Abstract
The effects of an antibiotic, neocarzinostatin (NCS), on cell division and DNA synthesis in synchronized and random culture of HeLa-S 3 cells were examined by using different methods of localizing the site of NCS-induced block of cell progress in their life cycles. It was found that the first site of action of NCS was the inhibition of DNA synthesis at early stage of S phase and the second site was the block at G 2 phase, almost one hr ahead of the block point of vinblastine sulfate. The block at G 2 phase by NCS was not dependent upon the inhibition of DNA synthesis by the antibiotic. The possibility that NCS affects microtubular proteins, resulting in both early S block and G 2 block in HeLa-S 3 cells is discussed.
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