Abstract
Objective: to reveal the specific features of the lymphocyte enzyme status in newborn infants with hypotrophic type of intrauterine growth retardation under the conditions of Yakutia. Subjects and methods. A total of 137 full-term newborns (including 28 babies with intrauterine growth retardation) whose parents were Yakutsk newcomers were examined on 1, 3 and 5 days of life. The cytochemical activity of lymphocyte enzymes, by determining the level of and time course of changes in succinate dehydrogenase (SDH), glycerol-3-phosphate dehydrogenase (GPDH), lactate dehydrogenase (LDH) and its aerobic isoenzyme (LDH-H), NADFH2-diaphorase, monoamine oxidase (MAO), and acid phosphatase (AP), were analyzed. Results. It was ascertained that the activity of SDH, GPDH, and LDH was higher on 5 day of life and that of NADFH2-diaphorase was lower in infants with intrauterine growth retardation than in apparently healthy neonates. Desynchronosis of the metabolic pathways was established in the dynamics of early ontogenesis. Conclusion. It is necessary to rationally correct standard treatment regimens, by taking into account the found metabolic features in infants with intrauterine growth retardation under the conditions of Yakutia.
Highlights
Specific features of the lymphocyte enzyme status in newborn infants with the hypotrophic type of intrauterine growth retardation
It was ascertained that the activity of succinate dehydrogenase (SDH), glycerol-3-phosphate dehydrogenase (GPDH), and lactate dehydrogenase (LDH) was higher on 5 day of life and that of NADFH2-diaphorase was lower in infants with intrauterine growth retardation than in apparently healthy neonates
Ros vestn perinatol i pediatr 2012; 57: 4(2): 119–125.)
Summary
Цель исследования: выявить особенности ферментного статуса лимфоцитов крови новорожденных детей с гипотрофическим вариантом задержки внутриутробного развития в условиях Якутии. Установлено, что у детей с задержкой внутриутробного развития в лимфоцитах крови повышена активность СДГ, ГФДГ, ЛДГ на 5-е сутки жизни и снижена активность НАДФ.Н2-диафоразы в сравнении со здоровыми новорожденными. Objective: to reveal the specific features of the lymphocyte enzyme status in newborn infants with hypotrophic type of intrauterine growth retardation under the conditions of Yakutia. Особенности ферментного статуса лимфоцитов крови новорожденных детей ном периоде [2,3,4,5]. Что публикаций, посвященных метаболической характеристике новорожденных детей с задержкой внутриутробного развития в условиях Севера, недостаточно [8], мы провели настоящее исследование.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
