Abstract
This paper considers the problem of creating a conductive matrix with a framework made of carbon nanotubes (CNTs) for cell and tissue engineering. In silico investigation of the electrical conductivity of the framework formed by T-junctions of single-walled carbon nanotubes (SWNTs) (12, 12) with a diameter of 1.5 nm has been carried out. A numerical evaluation of the contact resistance and electrical conductivity of seamless and suture T-junctions of SWCNTs is given. The effect of the type of structural defects in the contact area of the tubes on the contact resistance of the T-junction of SWCNTs was revealed. A coarse-grained model of a branched SWCNT network with different structure densities is constructed and its electrical conductivity is calculated. A new layered bioconstruction is proposed, the layers of which are formed by natural polymer matrixes: CNT-collagen, CNT-albumin and CNT-chitosan. The energy stability of the layered natural polymer matrix has been analyzed, and the adhesion of various layers to each other has been calculated. Based on the obtained results, a new approach has been developed in the formation of 3D electrically conductive bioengineering structures for the restoration of cell activity.
Highlights
The rapidly developing field of medical materials science is cell and tissue engineering, focused on the development of bio-artificial systems to restore the three-dimensional structure of tissue at the site of injury [1]
We investigate in silico the electroconductive layered natural polymer matrices, the framework of which is formed by a branched SWCNT network with T-junctions between tubes, and the filler is (1) albumin, (2) collagen, and (3) chitosan
The purpose of this work is to study the electrical conductivity of the carbon framework, the patterns of structure and energy for the conductive layered natural polymer matrix, as well as interlayer adhesion
Summary
The rapidly developing field of medical materials science is cell and tissue engineering, focused on the development of bio-artificial systems to restore the three-dimensional structure of tissue at the site of injury [1]. For successful use in tissue and cell engineering, matrices should have a controlled structure, be non-toxic, and be characterized by high strength, electrical conductivity, and thermal conductivity. In this regard, the actual problem of modern bioengineering is a search for materials to create the matrices. Unique electronic properties of CNTs are used to create biocompatible materials with high electrical conductivity [11,12]. We investigate in silico the electroconductive layered natural polymer matrices, the framework of which is formed by a branched SWCNT network with T-junctions between tubes, and the filler is (1) albumin, (2) collagen, and (3) chitosan. The purpose of this work is to study the electrical conductivity of the carbon framework, the patterns of structure and energy for the conductive layered natural polymer matrix, as well as interlayer adhesion
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