Abstract
BackgroundPeroxiredoxins (Prxs) have recently been suggested to have a role in tumorigenesis.MethodsWe studied the expression of Prx I-VI and their relationship to patient survival in 383 grade II-IV diffuse astrocytic brain tumors.ResultsPrx I positivity was found in 68%, Prx II in 84%, Prx III in 90%, Prx IV in 5%, Prx V in 4% and Prx VI in 47% of the tumors. Prx I and Prx II expression decreased significantly with increasing malignancy grade (p < 0.001 and p < 0.001). Patients with Prx I or Prx II positive tumors were significantly younger than the average age of all the patients (p = 0.014 and p = 0.005). A lower proliferation rate was associated with Prx I and Prx VI positive tumors (p = 0.019 and p = 0.033), and a lower apoptotic rate was found within Prx I and Prx II positive tumors (p < 0.001 and p = 0.007). Patients with Prx I and Prx II positive tumors had a significantly better survival rate than their Prx-negative counterparts (p = 0.0052 and p = 0.0002).ConclusionThe expression of Prx I and Prx II correlates with astrocytic tumor features, such as grade and patient age and proliferation activity (Prx I), and accordingly with patient survival.
Highlights
Peroxiredoxins (Prxs) have recently been suggested to have a role in tumorigenesis
We investigated the role of Prxs in a large series of diffusely infiltrating astrocytic brain tumors
Our results suggest that Prxs have a role in the behavior of astrocytic brain tumors, a role that seems to go beyond that of an antioxidant enzyme
Summary
Peroxiredoxins (Prxs) have recently been suggested to have a role in tumorigenesis. Infiltrating astrocytomas of grades II - IV are the most frequent primary brain tumors accounting for more than 30% of central nervous system tumors. They may develop at any age, the majority of astrocytomas manifest clinically in adults. Microglial cells and astrocytes have been shown weakly or moderately immunoreactive for Prx I and Prx VI, and oligodendrocytes for Prx I and Prx IV. Neurons do not seem to have immunoreactivity for Prx I and Prx VI, while all other Prxs are expressed weakly to moderately [9]
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