Abstract
Transgenic mice harboring the human hemopexin promoter sequences linked to the lacZ reporter gene were generated and analyzed for temporal and spatial distribution of β-galactosidase. Upstream sequences spanning from −1800, −700 and −500 bp to the transcription start point direct regulated β-galactosidase expression specifically to the liver and to the brain of transgenic mice. These results suggest that the 500 bp DNA fragment flanking the 5′end of the human hemopexin gene contains the cis-acting elements required for tissue and developmental stage-specific expressionin vivoand provide evidence for a new extrahepatic site of expression of the hemopexin gene.
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