Abstract
BackgroundMost hospital organizations have had to face the burden of managing the ongoing COVID-19 outbreak. One of the challenges in overcoming the influx of COVID-19 patients is controlling patient-to-staff transmission. Measuring the specific extent of ICU caregiver exposure to the virus and identifying the associated risk factors are, therefore, critical issues. We prospectively studied SARS-CoV-2 seroprevalence in the staff of a hospital in Lyon, France, several weeks after a first epidemic wave. Risk factors for the presence of SARS-CoV-2 antibodies were identified using a questionnaire survey.ResultsThe overall seroprevalence was 9% (87/971 subjects). Greater exposure was associated with higher seroprevalence, with a rate of 3.2% [95% CI 1.1–5.2%] among non-healthcare staff, 11.3% [8.9–13.7%] among all healthcare staff, and 16.3% [12.3–20.2%] among healthcare staff in COVID-19 units. The seroprevalence was dramatically lower (3.7% [1.0–6.7%]) in the COVID-19 ICU. Risk factors for seropositivity were contact with a COVID-19-confirmed household (odds ratio (OR), 3.7 [1.8–7.4]), working in a COVID-19 unit (OR, 3.5 [2.2–5.7], and contact with a confirmed COVID-19 coworker (OR, 1.9 [1.2–3.1]). Conversely, working in the COVID-19-ICU was negatively associated with seropositivity (OR, 0.33 [0.15–0.73]).ConclusionsIn this hospital, SARS-CoV-2 seroprevalence was higher among staff than in the general population. Seropositivity rates were particularly high for staff in contact with COVID-19 patients, especially those in the emergency department and in the COVID-19 unit, but were much lower in ICU staff.Clinical trial registration NCT04422977
Highlights
Most hospital organizations have had to face the burden of managing the ongoing COVID-19 outbreak
We report a large prospective study of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) seroprevalence among the staff of a city-center hospital in Lyon, France, where there was an influx of COVID-19 patients in March–April 2020
The main research questions were (i) whether seroprevalence was higher in healthcare personnel than in non-healthcare staff, (ii) whether working in units managing COVID-19 patients increased the risk of infection and (iii) whether a specific exposure was associated with working in intensive care unit
Summary
Most hospital organizations have had to face the burden of managing the ongoing COVID-19 outbreak. We prospectively studied SARS-CoV-2 seroprevalence in the staff of a hospital in Lyon, France, several weeks after a first epidemic wave. We report a large prospective study of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) seroprevalence among the staff of a city-center hospital in Lyon, France, where there was an influx of COVID-19 patients in March–April 2020. The aims of the study were to determine the overall SARS-COV-2 seroprevalence rate in the hospital staff, and to identify and quantify risk factors for symptomatic and asymptomatic staff infection. The main research questions were (i) whether seroprevalence was higher in healthcare personnel than in non-healthcare staff, (ii) whether working in units managing COVID-19 patients increased the risk of infection and (iii) whether a specific exposure was associated with working in intensive care unit
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