Abstract
Purpose: The purpose of the study was to examine the role of total tear IgE, and specific serum dog IgG and IgE antibodies on the severity of allergic conjunctivitis. Methods: This study enrolled healthy subjects (control group, N=13), the patients with seasonal allergic conjunctivitis (seasonal group, N=13), and patients with perennial allergic conjunctivitis (perennial group, N=13). Skin prick test, tear IgE level, and serum specific dog IgE and IgG levels were examined. The severity of allergic conjunctivitis using a grading score (0-30) was also examined. Results: The levels of serum dog-specific IgE and IgG, and total tear IgE of the seasonal and perennial groups were higher as compared to those of the control group (all p<0.05). The levels of serum dog-specific IgG of the perennial group were higher than those of the seasonal group (0.4 ± 0.6 vs. 0.0 ± 0.0). Multivariate analysis confirmed that the skin prick test result for dog allergen was related to the serum dog-specific IgG levels, but not IgE levels (p<0.01). The severity of allergic conjunctivitis was related to the serum level of dog-specific IgG antibodies (p<0.01). Conclusion: It was concluded that dog-specific IgG antibodies level may be associated with the severity of dog-related perennial allergic conjunctivitis.
Highlights
Immunoglobulins are complex proteins that recognize cell surface antigens and protect the host against various pathogens as well as against malignancy
A positive result for serum dog-specific IgE antibodies was significantly higher in the seasonal and perennial groups (30.8 and 38.5%) than in the control group (0.0%, p=0.0482) (Table 1)
Positivity for serum dog-specific IgG antibodies was significantly higher in the perennial group (30.8%) than in the control or seasonal group (0.0% and 0.0%, p=0.0116)
Summary
Immunoglobulins are complex proteins that recognize cell surface antigens and protect the host against various pathogens as well as against malignancy. IgG is involved in protection against infection by bacteria, fungi, and viruses through immobilization and opsonization of pathogens to which IgG antibodies bind. Specific IgG antibodies to viruses or other pathogens can be detected during the acute phase of infection. It has been reported IgG increased in Allergic conjunctivitis is classified as seasonal, perennial, or atopic conjunctivitis. IgE level increases in seasonal allergic conjunctivitis [2, 3]. It has been previously suggested that specific IgG antibodies may be involved in perennial allergic conjunctivitis by measuring the serum level of cat-specific IgE antibodies [10]
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