Abstract
Cognitive functioning influences activities of daily living (ADL). However, studies reporting the association between ADL and neuropsychological performance show inconsistent results regarding what specific cognitive domains are related to each specific functional domains. Additionally, whether depressive symptoms are associated with a worse functional performance in older adults is still under explored. We investigated if specific cognitive domains and depressive symptoms would affect different aspects of ADL. Participants were 274 older adults (96 normal aging participants, 85 patients with mild cognitive impairment, and 93 patients probable with mild Alzheimer’s disease dementia) with low formal education (∼4 years). Measures of ADL included three complexity levels: Self-care, Instrumental-Domestic, and Instrumental-Complex. The specific cognitive functions were evaluated through a factorial strategy resulting in four cognitive domains: Executive Functions, Language/Semantic Memory, Episodic Memory, and Visuospatial Abilities. The Geriatric Depression Scale measured depressive symptoms. Multiple linear regression analysis showed executive functions and episodic memory as significant predictors of Instrumental-Domestic ADL, and executive functions, episodic memory and language/semantic memory as predictors of Instrumental-Complex ADL (22 and 28% of explained variance, respectively). Ordinal regression analysis showed the influence of specific cognitive functions and depressive symptoms on each one of the instrumental ADL. We observed a heterogeneous pattern of association with explained variance ranging from 22 to 38%. Different instrumental ADL had specific cognitive predictors and depressive symptoms were predictive of ADL involving social contact. Our results suggest a specific pattern of influence depending on the specific instrumental daily living activity.
Highlights
Cognitive and functional impairments are hallmarks of cognitive disorders and defining features of mild cognitive impairment (MCI) and dementia
We investigated if specific cognitive domains and depressive symptoms would affect different aspects of activities of daily living (ADL)
The most usual form to assess functional performance in older adults is the investigation of activities of daily living (ADL), common activities performed by the majority of older adults in a specific cultural setting (Lawton and Brody, 1969)
Summary
Cognitive and functional impairments are hallmarks of cognitive disorders and defining features of mild cognitive impairment (MCI) and dementia. In MCI, the cognitive deficits do not impair the capacity to live independently, in contrast to individuals with dementia that present pronounced functional deficits, such as the ones observed in Alzheimer’s disease (AD; (Pereira et al, 2010; Brown et al, 2011; Seelye et al, 2013). Royall et al (2007) showed a weak to moderate association between global cognitive measures and functional impairment. Their results are heterogeneous with cognitive features responding for 0 to 80% of the variance in functional performance (mean of 21% with a SD of 20%; Gold, 2012). Methodological differences and sample characteristics might explain part of this excessive variability
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