Abstract
Recent studies suggest that lesions to the globus pallidus, lateral thalamus, ventrolateral thalamus, parafascicular thalamus, substantia nigra, or midbrain central gray in adult rats are associated with a nonspecific (generalized) learning impairment. The present study showed that lesions to any one of the foregoing structures, except the ventrolateral and parafascicular thalamus, in 21-day-old rats likewise produce a generalized learning impairment, as evidenced by significant deficits on a white-black discrimination, a nonvisual 11-deg incline-plane discrimination, and a 3-cul maze. A possible brain-injured animal model of mental retardation is discussed.
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