Abstract
Review presents data on medicines from the new group of cardiovascular drugs, direct oral anticoagulants (DOACs) inhibitors, as antidotes for DOAC when stopping life-threatening bleeding. DOAC therapy is accorded by hemorrhages with lower frequency than therapy by indirect anticoagulants, but really exist. New antidotes for DOACs are idarucizumab, andexanet, ciraparantag. The need in antidotes for DOAC may suddenly appear in spontaneous bleeding, during surgical operation, invasive procedure, due to trauma, in patients with stroke, kidney or liver failure. Data is given on the frequency of the main types of bleeding while taking new oral anticoagulants. Information concerning use of antidotes for DOACs in bleedings as well as use of non-specific therapy are reviewed.
Highlights
Для цитирования: Сумароков А.Б., Бурячковская Л.И., Ломакин Н.В
direct oral anticoagulants (DOACs) therapy is accorded by hemorrhages with lower frequency than therapy by indirect anticoagulants, but really exist
The need in antidotes for DOAC may suddenly appear in spontaneous bleeding, during surgical operation, invasive procedure, due to trauma, in patients with stroke, kidney or liver failure
Summary
Прием ПОАК сопровождается несколько меньшей частотой больших кровотечений, чем при терапии непрямыми антикоагулянтами, но их применение также несет риск геморрагий, представляющих угрозу жизни больного. Специфические антидоты для прямых оральных антикоагулянтов при угрожающих жизни кровотечениях. Specific Antidotes for Direct Oral Anticoagulants in Life-Threatening Bleeding Alexander B. Review presents data on medicines from the new group of cardiovascular drugs, direct oral anticoagulants (DOACs) inhibitors, as antidotes for DOAC when stopping life-threatening bleeding. For citation: Sumarokov A.B., Buryachkovskaya L.I., Lomakin N.V. Specific Antidotes for Direct Oral Anticoagulants in Life-Threatening Bleeding. Rational Pharmacotherapy in Cardiology 2018;14(6) / Рациональная Фармакотерапия в Кардиологии 2018;14(6). Antidotes for Direct Oral Anticoagulants Антидоты для прямых оральных антикоагулянтов ным, так как требования к контролю эффекта при назначении и длительном приеме препарата значительно ниже.
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