Abstract
This study was performed to review our experience with pediatric patients adaptive immunity to <em>Streptococcus pneumoniae</em> and <em>Haemophilus influenza</em> in the clinical presentation of chronic rhinosinusitis. Currently, there is no specific routine role in healthcare to check the immune status in patients after receiving the vaccinations.
Highlights
Most pediatric otolaryngologists struggle to treat a handful of patients with chronic rhinosinusitis (CRS)
Specific antibody deficiency to S. pneumoniae and H. influenza pathogens in pediatric patients with chronic rhinosinusitis had a high prevalence
We propose that if we review a sample population of pediatric patients with chronic rhinosinusitis, their reported titers to S. pneumoniae and H. influenza will be statistically lower than previously reported responses
Summary
Most pediatric otolaryngologists struggle to treat a handful of patients with chronic rhinosinusitis (CRS). If refractory disease is still present patients will typically be evaluated for an adenoidectomy or other sinus surgery depending on the extent of the disease [3]. While these treatments are effective, there continue to be patients who struggle controlling their symptoms even after going through surgery [4]. Immunogenicity rates for PCV 7 and 13 have been reported at 89% for children who receive the recommended doses with the geometric mean being observed at 1.3 mcg/mL [7]. Hib vaccination has been found to have a high rate of immunogenicity, 90% in a 5 year study [6]
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